Concepedia

Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer.

Masanori Tsujie, Shoji Nakamori, Shin Nakahira, Yûji Takahashi, Nobuyasu Hayashi, Jiro Okami, Hiroaki Nagano, Keizo Dono, Koji Umeshita, Masato Sakon,

PubMed · 2007 · 60 citations · 32 references

Abstract

Our results suggest that hENT1 plays an important role in 5-FU resistance and that hENT1 mRNA levels might be a useful marker to predict 5-FU sensitivity in pancreatic cancer.

References

32

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

Howard A. Burris, Malcolm J. Moore, John Sahl Andersen et al. · Journal of Clinical Oncology · 1997 · 5.8K citations

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

Dennis Salonga, Kathleen D. Danenberg, Martin R. Johnson et al. · PubMed · 2000 · 833 citations

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Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

P. G. Johnston, Heinz-Josef Lenz, Cynthia G. Leichman et al. · PubMed · 1995 · 678 citations

, , +16

Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.

John R. Mackey, Rajam S. Mani, M Selner et al. · PubMed · 1998 · 605 citations

, , +16

Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin.

Cynthia G. Leichman, Heinz-Josef Lenz, Lawrence Leichman et al. · Journal of Clinical Oncology · 1997 · 479 citations