Cynthia G. Leichman

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

Dennis Salonga, Kathleen D. Danenberg, Martin R. Johnson et al. · PubMed · 2000 · 833 citations

Pathology, Thymidylate Synthase, Cancer Biology +18

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

P. G. Johnston, Heinz-Josef Lenz, Cynthia G. Leichman et al. · PubMed · 1995 · 678 citations

Pathology, Thymidylate Synthase, Gastric Tumors +16

ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy.

R. Metzger, Cynthia G. Leichman, Kathleen D. Danenberg et al. · Journal of Clinical Oncology · 1998 · 510 citations

Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin.

Cynthia G. Leichman, Heinz-Josef Lenz, Lawrence Leichman et al. · Journal of Clinical Oncology · 1997 · 479 citations

Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study.

Cynthia G. Leichman, Thomas R. Fleming, Franco M. Muggia et al. · Journal of Clinical Oncology · 1995 · 360 citations