Decreased Interleukin‐2 Responses to <i>Fusobacterium nucleatum</i> and <i>Porphyromonas gingivalis</i> in Generalized Aggressive Periodontitis

Abstract

The decreased IL-2 responses of patients with GAgP to Pg and Fn combined with adequate IL-2 responses to TT suggest an impaired antigen-specific T-cell reactivity with periodontal pathogens in GAgP. The decreased IFN-gamma responses of smokers within the patient group suggest that smoking may aggravate this impairment.