Concepedia

NAD+ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study

Shuraila F. Zerp, Conchita Vens, Ben Floot, Marcel Verheij, Baukelien van Triest

Radiotherapy and Oncology · 2014 · 32 citations · 30 references

DOI

Concepts

References

30

The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells

Javier R. Revollo, Andrew A. Grimm, Shin‐ichiro Imai · Journal of Biological Chemistry · 2004 · 993 citations · Full text

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Poly(ADP-Ribose) in the Cellular Response to DNA Damage

Nathan A. Berger · Radiation Research · 1985 · 775 citations

, , +17

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.

Max Hasmann, Isabel Schemainda · PubMed · 2003 · 635 citations

, , +17

The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor

Kyle D. Holen, Leonard B. Saltz, Ellen Hollywood et al. · Investigational New Drugs · 2007 · 292 citations

, , +14

Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents

Javed Khan, Xiao Tao, Liang Tong · Nature Structural & Molecular Biology · 2006 · 260 citations

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