<i>BRAF</i> mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

Abstract

The BRAF mutation was frequently seen in SSA and in sporadic MSI-H CRC, both of which were associated with DNA methylation. Sporadic MSI-H cancers may originate in SSA and not adenomas, and BRAF mutation and DNA methylation are early events in this "serrated" pathway.