Decline in Number of Elevated Blood CD3⁺ CD56⁺ NKT Cells in Response to Intravenous Immunoglobulin Treatment Correlates with Successful Pregnancy

Abstract

Elevated NKT cells in recurrent pregnancy loss or implantation failure can be ameliorated with IVIG treatment, and result in successful pregnancy. Assay of NKT cell numbers may identify patients who are more likely to benefit from IVIG therapy and merits further examination in randomized phase II studies.