Concepedia

Leptin Interferes with the Effects of the Antiestrogen ICI 182,780 in MCF-7 Breast Cancer Cells

Cecilia Garofalo, Diego Sisci, Eva Surmacz

Clinical Cancer Research · 2004 · 139 citations · 44 references

DOI

Abstract

Leptin interferes with the effects of ICI 182,780 on estrogen receptor alpha in breast cancer cells. Thus, high leptin levels in obese breast cancer patients might contribute to the development of antiestrogen resistance.

References

44

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

Yongfeng Shang, Xiao Hu, James DiRenzo et al. · Cell · 2000 · 1.7K citations · Full text

, , +8

Biological Action of Leptin as an Angiogenic Factor

M. Rocı́o Sierra-Honigmann, Anjali K. Nath, Chiaki Murakami et al. · Science · 1998 · 1.4K citations

, , +16

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

Christian Bjørbæk, Shigeo Uotani, Bárbara da Silva et al. · Journal of Biological Chemistry · 1997 · 895 citations · Full text

Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting.

Madhur K. Sinha, Irina Opentanova, Joanna P. Ohannesian et al. · Journal of Clinical Investigation · 1996 · 541 citations · Full text

, , +19

Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover.

Sophie Dauvois, Paul S. Danielian, R White et al. · Proceedings of the National Academy of Sciences · 1992 · 472 citations · Full text

, , +15