Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

Christian Bjørbæk, Shigeo Uotani, Bárbara da Silva, +1

Journal of Biological Chemistry

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.

Shigeo Uotani, Jens Tornøe, Jeffrey S. Flier

Diabetes

Functional PropertiesAdipokinesGastrointestinal Peptide HormoneMolecular PharmacologyLeptin Internalization +20

In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin*

Young‐Bum Kim, Shigeo Uotani, Dominique D. Pierroz, +2

Endocrinology

Autoantibodies to Glutamic Acid Decarboxylase in Patients with IDDM and Autoimmune Thyroid Disease

Eiji Kawasaki, Hirofumi Takino, Mayumi Yano, +6

Diabetes

ImmunologyPathologyInsulin SignalingAutoantibodiesIddm Patients +14

Association between IL-18 gene promoter polymorphisms and CTLA-4 gene 49A/G polymorphism in Japanese patients with type 1 diabetes

Akane Ide, Eiji Kawasaki, Norio Abiru, +11

Journal of Autoimmunity

Type 1Genetic DeterminantDiabetes EpidemiologyAutoimmune DiseaseGenetics +12

High-dose but not low-dose dexamethasone impairs glucose tolerance by inducing compensatory failure of pancreatic beta-cells in normal men.

Kazunari Matsumoto, Hironori Yamasaki, Satoru Akazawa, +8

The Journal of Clinical Endocrinology & Metabolism

Glucose DisappearanceGlucocorticoidNormal MenMetabolic SyndromeMetabolism +14

Functional Properties of Leptin Receptor Isoforms Containing the Gln→Pro Extracellular Domain Mutation of the Fatty Rat*

Barbara A. da Silva, Christian Bjørbæk, Shigeo Uotani, +1

Endocrinology

Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-β and tumor necrosis factor-α

Atsushi Kita, Hironori Yamasaki, Hironaga Kuwahara, +9

Biochemical and Biophysical Research Communications

Transcriptional RegulationPromoter RegionBiochemistryMedicineNatural Sciences +7

Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onset

Akane Ide, Eiji Kawasaki, Norio Abiru, +11

Human Immunology

Metabolic SyndromeGenetic DeterminantDiabetes EpidemiologyGeneticsDiabetes +10

Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway

Shigeo Uotani, Takahiro Abe, Yoshihiko Yamaguchi

Biochemical and Biophysical Research Communications

Jak2-dependent PathwayGastrointestinal Peptide HormoneSignal TransductionHepatologyMolecular Physiology +11