Long-Term Estradiol Exposure Is a Direct Mitogen for Insulin/EGF-Primed Endometrial Cells and Drives PTEN Loss-Induced Hyperplasic Growth

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

Shigeaki Kato, Hideki Endoh, Yoshikazu Masuhiro et al. · Science · 1995 · 2K citations

Pten is essential for embryonic development and tumour suppression

Antonio Di Cristofano, Bárbara Pesce, Carlos Cordon‐Cardo et al. · Nature Genetics · 1998 · 1.5K citations

Developmental Biology, Cell Proliferation, Tumour Suppression +4

Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

Giuseppe Bunone, P. A. Briand, Richard J. Miksicek et al. · The EMBO Journal · 1996 · 988 citations · Full text

Developmental Biology, Molecular Physiology, Signal Transduction +9

Mutation of<i>Pten/Mmac1</i>in mice causes neoplasia in multiple organ systems

Katrina Podsypanina, Lora H. Ellenson, Adriana Nemes et al. · Proceedings of the National Academy of Sciences · 1999 · 947 citations

PTEN-Mediated Apical Segregation of Phosphoinositides Controls Epithelial Morphogenesis through Cdc42

Fernando Martı́n-Belmonte, Ama Gassama, Anirban Datta et al. · Cell · 2007 · 692 citations · Full text

Signal Transduction, Developmental Biology, Signaling Pathway +9