Shorter telomeres, accelerated ageing and increased lymphoma in DNA‐PKcs‐deficient mice

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

André Nussenzweig, Changhu Chen, Vera da Costa Soares et al. · Nature · 1996 · 670 citations

Life Sciences, Immunology, Molecular Biology +14

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

Eloı́sa Herrera · The EMBO Journal · 1999 · 465 citations

Life Sciences, Genetics, Molecular Biology +14

A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination

Yijie Gao, Jayanta Chaudhuri, Chengming Zhu et al. · Immunity · 1998 · 439 citations · Full text

Life Sciences, Genetics, Molecular Biology +11

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

Chengming Zhu, Molly A. Bogue, Dae‐Sik Lim et al. · Cell · 1996 · 430 citations · Full text

Life Sciences, Genetics, Immunology +14

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

Yansong Gu, Shengfang Jin, Yijie Gao et al. · Proceedings of the National Academy of Sciences · 1997 · 401 citations

Life Sciences, Genetics, Molecular Biology +17