T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

Diana Finzi, Joel N. Blankson, Janet D. Siliciano et al. · Nature Medicine · 1999 · 2.1K citations

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Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

Tae‐Wook Chun, Lieven Stuyver, Stephanie B. Mizell et al. · Proceedings of the National Academy of Sciences · 1997 · 2K citations

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Dirk Grimm, Konrad L. Streetz, Catherine L. Jopling et al. · Nature · 2006 · 1.7K citations

Life Sciences, Genetics, Molecular Biology +8

Transvascular delivery of small interfering RNA to the central nervous system

Priti Kumar, Haoquan Wu, Jodi L. McBride et al. · Nature · 2007 · 1.2K citations

Pharmacy, Molecular Biology, Pharmaceutics +17

RNA interference targeting Fas protects mice from fulminant hepatitis

Erwei Song, Sang‐Kyung Lee, Jie Wang et al. · Nature Medicine · 2003 · 1.1K citations

Life Sciences, Immunology, Molecular Biology +15