Effect of a second-generation α ₂ δ ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome

Abstract

Pregabalin increased distension sensory thresholds to normal levels in IBS patients with rectal hypersensitivity. A concomitant increase in rectal compliance appeared to be unrelated to the reduction in sensitivity. These data suggest that alpha(2)delta ligands are worthy of further investigation in the treatment of visceral pain disorders, including IBS.