Concepedia

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

Anna Jirkovská, Jaroslav Roh, Olga Lenčová-Popelová, Eduard Jirkovský, Kateřina Hrušková, Eliška Potůčková-Macková, Hana Jansová, Pavlína Hašková, Pavla Martinková, Tomáš Eisner,

Toxicology Research · 2015 · 22 citations · 47 references

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Concepts

Abstract

Topoisomerase II beta, rather than (or along with) iron chelation, may be a promising target for cardioprotection.

References

47

Free radicals in biology and medicine

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Identification of the molecular basis of doxorubicin-induced cardiotoxicity

Sui Zhang, Xiaobing Liu, Tasneem Bawa‐Khalfe et al. · Nature Medicine · 2012 · 1.9K citations

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An enzyme-release assay for natural cytotoxicity

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Free Radicals in Biology and Medicine

Peter Kovacic · Journal of Pharmaceutical Sciences · 1986 · 982 citations

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Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia

Robert E. Gallagher, Steven Collins, José M. Trujillo et al. · Blood · 1979 · 917 citations · Full text

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