Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation

Eduard Jirkovský, Anna Jirkovská, Hana Bavlovič Piskáčková, +13

Circulation Heart Failure

Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury

Hana Jansová, Miloslav Macháček, Qin Wang, +6

Free Radical Biology and Medicine

Cardiomyocyte Oxidative InjuryVarious Iron ChelatorsHeart FailureBiochemistryMedicine +9

Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite

Jan Bureš, Anna Jirkovská, Vít Šesták, +6

Toxicology

Significant Cardioprotective EffectsBiochemistryIron Chelating MetaboliteMedicineClinical Pharmacology +7

Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model

Juraj Lenčo, Olga Lenčová-Popelová, Marek Link, +6

Experimental Cell Research

Embryonic Stem CellCell LineageHuman CellDevelopmental BiologyMolecular Phenotype +8

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

Anna Jirkovská, Jaroslav Roh, Olga Lenčová-Popelová, +18

Toxicology Research

Heart FailureChemoprevention StrategyAnthracycline CardiotoxicityNovel AnaloguesPharmacotherapy +14

Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane

Olga Lenčová-Popelová, Eduard Jirkovský, Hana Jansová, +10

Journal of Molecular and Cellular Cardiology

Heart FailureReactive Nitrogen SpecieMedicineChronic Anthracycline CardiotoxicityInorganic Nitrate/nitrite +6

Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart

Eduard Jirkovský, Anna Jirkovská, Jan Bureš, +10

Journal of Pharmacology and Experimental Therapeutics

Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions

Anna Jirkovská, Galina Karabanovich, Jan Kubeš, +12

Journal of Medicinal Chemistry

Structure-Activity Relationships of Novel Salicylaldehyde Isonicotinoyl Hydrazone (SIH) Analogs: Iron Chelation, Anti-Oxidant and Cytotoxic Properties

Eliška Potůčková, Kateřina Hrušková, Jan Bureš, +15

PLoS ONE

Chemoprevention StrategyChemistryRedox BiologyPharmaceutical ChemistryTumor Biology +17

Detection and quantitation of iron in ferritin, transferrin and labile iron pool (LIP) in cardiomyocytes using 55Fe and storage phosphorimaging

Matyáš Krijt, Anna Jirkovská, T. Kabickova, +3

Biochimica et Biophysica Acta (BBA) - General Subjects

Iron DeficiencyBiochemistryIron MetabolismBioanalysisPhysiology +9