Anti‐inflammatory and anti‐osteoclastogenic effects of zinc finger protein <scp>A</scp>20 overexpression in human periodontal ligament cells

Abstract

This study is the first to demonstrate that A20 overexpression has anti-inflammatory effects and blocks osteoclastic differentiation in a nicotine- and LPS-stimulated hPDLC model. Thus, A20 overexpression may be a potential therapeutic target in inflammatory bone loss diseases, such as periodontal disease.