Calorie restriction and Roux‐en‐Y gastric bypass have opposing effects on circulating <scp>FGF</scp>21 in morbidly obese subjects

Abstract

Calorie restriction and RYGB have opposite effects on serum bile salt and FGF21 levels. Calorie restriction results in FGF21 approaching nonobese control levels, suggesting that this intervention is effective in reducing the "nutritional crisis" that appears to underly FGF21 elevation in obesity. FGF21 elevation after RYGB may contribute to the beneficial effect of this procedure.