Concepedia
European Journal of Cancer and Clinical Oncology · 1988 · 21 citations · 4 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryStructure-activity RelationshipsDrug-metabolizing EnzymesMedicinal Chemistry Applications
4
A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice
Terence R. Jones, A H Calvert, Ann L. Jackman et al. · European Journal of Cancer (1965) · 1981 · 239 citations
Life Sciences, Medicinal Chemistry, Pharmacology +7
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
H. Diddens, D. Niethammer, Robert Jackson · PubMed · 1983 · 100 citations
Medicine, Oncology, Pharmacology +14
The clinical pharmacokinetics of the novel antifolate N10-propargyl-5,8-dideazafolic acid (CB 3717)
DavidR. Newell, C. Sessa, S.J. Harland et al. · Cancer Chemotherapy and Pharmacology · 1985 · 43 citations
Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +4
Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717
Nicola J. Curtin, Adrian L. Harris, Oliver James et al. · British Journal of Cancer · 1986 · 13 citations · Full text
Medicine, Oncology, Pharmacology +11