Single-Nucleotide Polymorphism in the <i>fadD28</i> Gene as a Genetic Marker for East Asia Lineage <i>Mycobacterium tuberculosis</i>

Abstract

Mycobacterium tuberculosis isolates with a region of difference 105 (RD105) deletion, mainly Beijing family spoligotypes, were phylogenetically grouped into the East Asia lineage. We identified a single nucleotide polymorphism in codon 507, ATC to ATT, of the fadD28 gene as a robust marker and developed a rapid assay for East Asia lineage M. tuberculosis.