An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

Toshiyuki Nakagawa, Hong Zhu, Nobuhiro Morishima et al. · Nature · 2000 · 3.2K citations

Apoptosis, Cell Death, Degenerative Pathology +5

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Joyce W. Lustbader, Maurizio Cirilli, Chang Lin et al. · Science · 2004 · 1.3K citations

Mitochondrial Dysfunction, Molecular Biology, Cell Death +18

Cross-Talk between Two Cysteine Protease Families

Toshiyuki Nakagawa, Junying Yuan · The Journal of Cell Biology · 2000 · 1.2K citations · Full text

Neurotoxicity induces cleavage of p35 to p25 by calpain

Ming‐Sum Lee, Young T. Kwon, Mingwei Li et al. · Nature · 2000 · 1.1K citations

Biochemistry, Medicine, Neuropharmacology +4

Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

Yuesong Gong, Lei Chang, Kirsten L. Viola et al. · Proceedings of the National Academy of Sciences · 2003 · 1K citations · Full text