Substrate‐Dependent Nonlinear Effects in Proline–Thiourea‐Catalyzed Aldol Reactions: Unraveling the Role of the Thiourea Co‐Catalyst

Abstract

It's an affair of four: The study of nonlinear effects in the proline–thiourea-catalyzed aldol reaction between acetone and aromatic aldehydes, together with NMR and ESI-MS experiments, shows that the main role of the thiourea co-catalyst is that of promoting both the formation of a soluble Seebach's oxazolidinone intermediate and its conversion into the iminium carboxylate isomer. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.