Blood–brain barrier P-glycoprotein function decreases in specific brain regions with aging: A possible role in progressive neurodegeneration

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity <i>in</i> <i>vivo</i>

Sven Hoffmeyer, Oliver Burk, Oliver von Richter et al. · Proceedings of the National Academy of Sciences · 2000 · 2.4K citations

Medicine, Molecular Genetics, Pharmacology +15

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Comparing Functional (PET) Images: The Assessment of Significant Change

Karl Friston, Chris Frith, Peter F. Liddle et al. · Journal of Cerebral Blood Flow & Metabolism · 1991 · 1.6K citations · Full text

Medicine, Neurology, Neuroscience +15

Imaging β-amyloid burden in aging and dementia

C. C. Rowe, Sally Ng, Uwe Ackermann et al. · Neurology · 2007 · 1.1K citations

Medicine, Neurology, Neuroscience +17

Age-related alterations in white matter microstructure measured by diffusion tensor imaging

David H. Salat, David S. Tuch, Douglas N. Greve et al. · Neurobiology of Aging · 2004 · 857 citations

Medicine, Neuroscience, Radiology +16