Concepedia

Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group

Ramakrishna G. Bhat, Surajit Sinha, Srinivasan Chandrasekaran

Chemical Communications · 2002 · 26 citations · 7 references

DOI

Concepts

Abstract

Synthesis of short peptides using propargyloxycarbonyl amino acid chlorides as effective coupling reagents and polymer supported tetrathiomolybdate as an efficient deblocking agent are reported.

References

7

[(9-Fluorenylmethyl)oxy]carbonyl (FMOC) amino acid fluorides. Convienient new peptide coupling reagents applicable to the FMOC/tert-butyl strategy for solution and solid-phase syntheses.

Louis A. Carpino, Dean Sadat-Aalaee, Hann Guang Chao et al. · Journal of the American Chemical Society · 1990 · 236 citations

, , +11

PyBOP® and PyBroP: Two reagents for the difficult coupling of the α,α-dialkyl amino acid, Aib.

Eric Frérot, J. H. Coste, Antoine Pantaloni et al. · Tetrahedron · 1991 · 227 citations

, , +3

(Fluoren-9-ylmethoxy)carbonyl (Fmoc) amino acid chlorides. Synthesis, characterization, and application to the rapid synthesis of short peptide segments

Louis A. Carpino, B. J. Cohen, K. E. JUN. STEPHENS et al. · The Journal of Organic Chemistry · 1986 · 193 citations

, , +9

Comparative study of methods to couple hindered peptides

Jeffrey R. Spencer, Valery V. Antonenko, Nancy G. J. Delaet et al. · International journal of peptide & protein research · 1992 · 75 citations

, , +14

Heteroarene-2-sulfonyl Chlorides (BtsCl; ThsCl):  Reagents for Nitrogen Protection and &gt;99% Racemization-Free Phenylglycine Activation with SOCl<sub>2</sub>

Edwin Vedējs, Shouzhong Lin, Artis Klapars et al. · Journal of the American Chemical Society · 1996 · 56 citations

, , +4