Concepedia

Peptide Deprotection

Peptide Deprotection is a chemical process in peptide synthesis whereby temporary protecting groups are selectively removed from amino acid side chains or the peptide backbone to enable subsequent coupling or cyclization steps while preserving the integrity of the peptide structure.

336

Publications

14.7K

Citations

1K

Authors

287

Institutions

Publications per year

2017–2026

30

Parents

Publications

336

A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis

David S. King, Cynthia G. Fields, Gregg Fields · International journal of peptide & protein research · 1990 · 726 citations

, , +12

An SN2 deprotection of synthetic peptides with a low concentration of hydrofluoric acid in dimethyl sulfide: evidence and application in peptide synthesis

James P. Tam, William F. Heath, R. B. Merrifield · Journal of the American Chemical Society · 1983 · 546 citations

, , +10

Use of Anhydrous Hydrogen Fluoride in Peptide Synthesis. I. Behavior of Various Protective Groups in Anhydrous Hydrogen Fluoride

Shumpei Sakakibara, Yasutsugu Shimonishi, Yasuo Kishida et al. · Bulletin of the Chemical Society of Japan · 1967 · 391 citations

, , +16

Mechanisms for the removal of benzyl protecting groups in synthetic peptides by trifluoromethanesulfonic acid-trifluoroacetic acid-dimethyl sulfide

James P. Tam, William F. Heath, R. B. Merrifield · Journal of the American Chemical Society · 1986 · 285 citations

, , +10

Gateway Reactions to Diverse, Polyfunctional Monolayer-Protected Gold Clusters

Allen C. Templeton, Michael J. Hostetler, Emily K. Warmoth et al. · Journal of the American Chemical Society · 1998 · 267 citations

, , +15

1–5 of 336

Authors

1K

  1. JP
    James P. Tam

    Nanyang Technological University, Singapore

    17 publications · 1.4K citations

    14

    h-index

  2. RB
    R. B. Merrifield

    Rockefeller University, United States

    16 publications · 1.4K citations

    13

    h-index

  3. FA
    Fernando Alberício

    Universitat de Barcelona, Spain

    10 publications · 502 citations

    10

    h-index

  4. HY
    Haruaki Yajima

    Kyoto University, Japan

    9 publications · 338 citations

    9

    h-index

  5. NF
    Nobutaka Fujii

    Kyoto University, Japan

    9 publications · 440 citations

    9

    h-index

1–5 of 1K

Institutions

287

  1. Rockefeller University

    New York, United States

    13 h-index

    37 publications

    1.6K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    36 publications

    1.3K citations

  3. Universitat de Barcelona

    Barcelona, Spain

    10 h-index

    31 publications

    1.5K citations

  4. Kyoto University

    Kyoto, Japan

    10 h-index

    56 publications

    1.8K citations

  5. Johannes Gutenberg University Mainz

    Mainz, Germany

    9 h-index

    20 publications

    880 citations

  6. The University of Osaka

    Osaka, Japan

    8 h-index

    32 publications

    3K citations

  7. Kyoto Pharmaceutical University

    Kyoto, Japan

    8 h-index

    39 publications

    772 citations

  8. Max Planck Society

    Munich, Germany

    7 h-index

    15 publications

    1.1K citations

1–8 of 287

Venues

  1. Tetrahedron Letters

    43 publications · 1.9K citations

    26

    h-index

  2. 21

    h-index

  3. The Journal of Organic Chemistry

    JOC · 18 publications · 754 citations

    16

    h-index

  4. Organic Letters

    OL · 15 publications · 654 citations

    14

    h-index

  5. Journal of Peptide Science

    17 publications · 559 citations

    14

    h-index

1–5