Aminomethylpyridines as DPP-IV inhibitors

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.

Michael A. Nauck, Markus M. Heimesaat, Jens J. Holst et al. · Journal of Clinical Investigation · 1993 · 1.6K citations · Full text

Medicine, Endocrinology, Pharmacology +15

Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum

Rolf Mentlein, Baptist Gallwitz, Wolfgang E. Schmidt · European Journal of Biochemistry · 1993 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

Timothy J. Kieffer, Christopher H.S. McIntosh, Raymond A. Pederson · Endocrinology · 1995 · 1.1K citations

Life Sciences, Biochemistry, Endocrinology +17

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

Daniel J. Drucker, Jan Philippé, Svetlana Mojsov et al. · Proceedings of the National Academy of Sciences · 1987 · 891 citations · Full text

Life Sciences, Endocrinology, Physiology +17

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

Svetlana Mojsov, Gordon C. Weir, Joel F. Habener · Journal of Clinical Investigation · 1987 · 871 citations · Full text

Life Sciences, Biochemistry, Endocrinology +16