LXR Activation Reduces Proinflammatory Cytokine Expression in Human CD4-Positive Lymphocytes

Abstract

Human CD4-positive lymphocytes express both LXRalpha and LXRbeta, and LXR activation can reduce Th-1 cytokine expression in these cells. These data provide new insight how LXR activators might modulate the inflammatory process in atherogenesis and as such influence lesion development.