Inhibitor Binding in the Human Renal Low- and High-Affinity Na+/Glucose Cotransporters

Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.

Luciano Rossetti, Douglas J. Smith, Gerald I. Shulman et al. · Journal of Clinical Investigation · 1987 · 808 citations · Full text

Medicine, Endocrinology, Pharmacology +16

The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose.

Y. Kanai, W S Lee, Dennis Brown et al. · Journal of Clinical Investigation · 1994 · 624 citations · Full text

Life Sciences, Molecular Biology, Physiology +15

Molecular Analysis of the SGLT2 Gene in Patients with Renal Glucosuria

René Santer, Martina Kinner, C.L. Lassen et al. · Journal of the American Society of Nephrology · 2003 · 300 citations

Medicine, Genetics, Molecular Genetics +17

Sergliflozin, a Novel Selective Inhibitor of Low-Affinity Sodium Glucose Cotransporter (SGLT2), Validates the Critical Role of SGLT2 in Renal Glucose Reabsorption and Modulates Plasma Glucose Level

Kenji Katsuno, Yoshikazu Fujimori, Yukiko Takemura et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 266 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.

Akira Oku, Kiichiro Ueta, Kenji Arakawa et al. · Diabetes · 1999 · 253 citations

Medicine, Pharmacology, Pharmacotherapy +17