Concepedia

The Therapeutic Effect of Anti-HER2/neu Antibody Depends on Both Innate and Adaptive Immunity

SaeGwang Park, Zhujun Jiang, Eric D. Mortenson, Liufu Deng, Olga Radkevich-Brown, Xuanming Yang, Husain Sattar, Yang Wang, Nicholas K. Brown, Mark I. Greene,

Cancer Cell · 2010 · 590 citations · 40 references

Open access

Concepts

Life SciencesImmunologyPathologyAdaptive ImmunityImmunotherapyInnate ImmunityAdaptive Immune ResponsesHer2-positive Breast CancerHumoral ImmunityInnate Immune ActivationInnate Immune ModulationInnate Immune Signaling PathwaysAdaptive Antitumor ImmunityHer2 InhibitorsHer2 Receptor TargetingHer2-positive Breast Cancer ImmunotherapyHer2-positive Breast Cancer TherapyImmune Effector Functions

References

40

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/<i>neu</i>Oncogene

Dennis J. Slamon, Gary M. Clark, Steven Wong et al. · Science · 1987 · 11.7K citations

Medicine, Genetics, Oncology +14

Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer

Edward H. Romond, Edith A. Perez, John Bryant et al. · New England Journal of Medicine · 2005 · 5.4K citations · Full text

Medicine, Oncology, Pharmacotherapy +17

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

Martine Piccart, Marion Procter, Brian Leyland‐Jones et al. · New England Journal of Medicine · 2005 · 5.1K citations · Full text

Medicine, Oncology, Pharmacology +16

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Lionel Apétoh, François Ghiringhelli, Antoine Tesnière et al. · Nature Medicine · 2007 · 3K citations

Life Sciences, Immunology, Oncology +16

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

Raphael Clynes, Terri L. Towers, Leonard G. Presta et al. · Nature Medicine · 2000 · 2.7K citations

Medicine, Cancer Biology, Oncology +15