Concepedia

Arginine-linked neomycin B dimers: synthesis, rRNA binding, and resistance enzyme activity

Yi Jin, Derrick Watkins, Natalya N. Degtyareva, Keith Green, Meredith Newby Spano, Sylvie Garneau‐Tsodikova, Dev P. Arya

MedChemComm · 2015 · 22 citations · 44 references

DOI

Concepts

Abstract

New dimeric aminoglycosides conjugated to arginine were synthesized and found to efficiently bind to human and bacterial RNA A-site and to evade the activity of resistance enzymes.

References

44

Interaction of antibiotics with functional sites in 16S ribosomal RNA

Danesh Moazed, Harry F. Noller · Nature · 1987 · 1.1K citations

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Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives

Sylvie Garneau‐Tsodikova, Kristin Jansen Labby · MedChemComm · 2015 · 579 citations · Full text

, , +16

Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding

Boris François · Nucleic Acids Research · 2005 · 339 citations · Full text

, , +17

Binding of tRNA to the ribosomal A and P sites protects two distinct sets of nucleotides in 16 S rRNA

Danesh Moazed, Harry F. Noller · Journal of Molecular Biology · 1990 · 292 citations

, , +7

Mutations in 16S ribosomal RNA disrupt antibiotic–RNA interactions.

Elizabeth A. De Stasio, Danesh Moazed, Harry F. Noller et al. · The EMBO Journal · 1989 · 163 citations

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