Concepedia

Affinity Screening

Affinity Screening is a methodological process in molecular biology that selects high-affinity ligands by isolating ribosome-bound polypeptides displaying specific binding activity to a target molecule from a diverse library.

421

Publications

19.6K

Citations

2.6K

Authors

670

Institutions

Publications per year

2017–2026

137

Parents

Publications

421

The use of mRNA display to select high-affinity protein-binding peptides

David Sloan Wilson, Anthony D. Keefe, Jack W. Szostak · Proceedings of the National Academy of Sciences · 2001 · 413 citations · Full text

, , +14

Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display

Jozef Hanes, Christiane Schaffitzel, Achim Knappik et al. · Nature Biotechnology · 2000 · 372 citations

, , +16

Privileged Molecules for Protein Binding Identified from NMR-Based Screening

Philip J. Hajduk, Mark G. Bures, Jens Praestgaard et al. · Journal of Medicinal Chemistry · 2000 · 350 citations · Full text

, , +17

Ribosome display efficiently selects and evolves high-affinity antibodies <i>in vitro</i> from immune libraries

Jozef Hanes, Lutz Jermutus, Susanne Weber-Bornhauser et al. · Proceedings of the National Academy of Sciences · 1998 · 289 citations

, , +15

Identification and characterization of the calmodulin-binding domain of neuromodulin, a neurospecific calmodulin-binding protein.

Kenneth Alexander, Bassam T. Wakim, Geraldine Doyle et al. · Journal of Biological Chemistry · 1988 · 260 citations · Full text

, , +16

1–5 of 421

Authors

2.6K

  1. AN
    Anuraj Nayarisseri

    Alagappa University, India

    6 publications · 201 citations

    6

    h-index

  2. AP
    Andreas Plückthun

    University of Zurich, Switzerland

    5 publications · 825 citations

    5

    h-index

  3. EN
    Elliott Nickbarg

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    5 publications · 299 citations

    5

    h-index

  4. DN
    Dario Neri

    ETH Zurich, Switzerland

    5 publications · 292 citations

    5

    h-index

  5. JS
    Jörg Scheuermann

    ETH Zurich, Switzerland

    5 publications · 292 citations

    5

    h-index

1–5 of 2.6K

Institutions

670

  1. Chinese Academy of Sciences

    Beijing, China

    7 h-index

    56 publications

    1.4K citations

  2. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    7 h-index

    62 publications

    4.3K citations

  3. University of Cambridge

    Cambridge, United Kingdom

    6 h-index

    25 publications

    1.6K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    32 publications

    1K citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    6 h-index

    32 publications

    1.4K citations

  6. Philochem (Switzerland)

    Otelfingen, Switzerland

    6 h-index

    17 publications

    830 citations

  7. King Saud University

    Riyadh, Saudi Arabia

    6 h-index

    11 publications

    810 citations

  8. University at Buffalo, State University of New York

    Buffalo, United States

    6 h-index

    17 publications

    967 citations

1–8 of 670

Venues

  1. Journal of Medicinal Chemistry

    40 publications · 2.6K citations

    28

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 2.2K citations

    16

    h-index

  3. Biochemistry

    12 publications · 697 citations

    12

    h-index

  4. Analytical Chemistry

    11 publications · 635 citations

    11

    h-index

  5. SLAS DISCOVERY

    12 publications · 480 citations

    11

    h-index

1–5