Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang, S.M. Soisson, Katherine Young et al. · Nature · 2006 · 815 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9

Discovery of platencin, a dual FabF and FabH inhibitor with <i>in vivo</i> antibiotic properties

Jun Wang, Srinivas Kodali, Sang Ho Lee et al. · Proceedings of the National Academy of Sciences · 2007 · 380 citations · Full text

Life Sciences, Microbiology, Pharmacology +14

Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy

Sheo B. Singh, Hiranthi Jayasuriya, John G. Ondeyka et al. · Journal of the American Chemical Society · 2006 · 231 citations

Life Sciences, Biochemistry, Microbiology +13

Discovery of FabH/FabF Inhibitors from Natural Products

Katherine Young, Hiranthi Jayasuriya, John G. Ondeyka et al. · Antimicrobial Agents and Chemotherapy · 2006 · 200 citations · Full text

Life Sciences, Microbiology, Molecular Biology +14

Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad‐Spectrum Antibiotic Activity

Hiranthi Jayasuriya, Kithsiri Herath, Chaowei Zhang et al. · Angewandte Chemie International Edition · 2007 · 196 citations

Pharmacy, Medicinal Chemistry, Pharmacology +7