Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad‐Spectrum Antibiotic Activity

Abstract

Two birds with one stone: Platencin (1) is a novel and potent broad-spectrum Gram-positive antibiotic. Whereas platensimycin is a selective inhibitor of FabF, platencin exerts its activity by a novel mode of action by dual inhibition of FabH and FabF. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701058_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.