Essential Role of Junctional Adhesion Molecule-1 in Basic Fibroblast Growth Factor–Induced Endothelial Cell Migration

Abstract

Our results show that JAM-1 is required for the bFGF-induced ERK activation that leads to endothelial cell migration on vitronectin. These data thus implicate JAM-1 as an integral part of both bFGF and ERK signaling pathways in endothelial cells.