Concepedia

COMT genotypes and use of antipsychotic medication: linking population‐based prescription database to the HUNT study

Knut Hagen, Lars Jacob Stovner, Frank Skorpen, Elin Pettersen, John‐Anker Zwart

Pharmacoepidemiology and Drug Safety · 2008 · 11 citations · 19 references

DOI

Abstract

In this population-based cohort of 2623 adults, the Val158Met polymorphism at the COMT gene had no major impact on number of individuals who had been prescribed antipsychotic medication. However, linkage to the prescription database may in an indirect way indicate an association between the COMT Val158Met polymorphism and treatment response or dose requirements of antipsychotic medication.

References

19

Kinetics of Human Soluble and Membrane-Bound Catechol O-Methyltransferase: A Revised Mechanism and Description of the Thermolabile Variant of the Enzyme

Timo Lotta, Jukka Vidgren, Carola Tilgmann et al. · Biochemistry · 1995 · 1.2K citations

A Highly Significant Association between a COMT Haplotype and Schizophrenia

Sagiv Shifman, Michal Bronstein, Meira Sternfeld et al. · The American Journal of Human Genetics · 2002 · 696 citations · Full text

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The Nord-Trøndelag Health Study 1995-97 (HUNT 2): Objectives, contents, methods and participation

Jostein Holmen, Kristian Midthjell, Øystein Krüger et al. · 2003 · 532 citations

, , +24

Interaction of COMT Val<sup>108/158</sup> Met Genotype and Olanzapine Treatment on Prefrontal Cortical Function in Patients With Schizophrenia

Alessandro Bertolino, Grazia Caforio, Giuseppe Blasi et al. · American Journal of Psychiatry · 2004 · 273 citations

Association Between Catechol <b><i>O</i></b>-Methyltransferase Genotype and Violence in Schizophrenia and Schizoaffective Disorder

Herbert M. Lachman, Karen A. Nolan, Pavel Mohr et al. · American Journal of Psychiatry · 1998 · 198 citations · Full text