Concepedia

A multivalent lacto-N-fucopentaose III-lysyllysine conjugate decompacts preimplantation mouse embryos, while the free oligosaccharide is ineffective.

B A Fenderson, Uri Zehavi, S Hakomori

The Journal of Experimental Medicine · 1984 · 289 citations · 16 references

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Concepts

Abstract

A multivalent lacto-N-fucopentaose (LNFP) III-lysyllysine conjugate was observed to decompact preimplantation mouse embryos. Decompaction was not obtained with free oligosaccharides (LNFP II and III), nor with multivalent LNFP II-lysyllysine or chitotriose-lysyllysine conjugates. These results suggest a role for X hapten recognition during compaction and suggest further that X hapten valency may play a key role in modulating this developmental process.

References

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Davor Solter, Barbara B. Knowles · Proceedings of the National Academy of Sciences · 1978 · 1.3K citations · Full text

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Stage-specific embryonic antigen involves αl→ 3 fucosylated type 2 blood group chains

H.C. Gooi, Ten Feizi, Ashni Kapadia et al. · Nature · 1981 · 607 citations

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Stage‐specific embryonic antigens (SSEA‐3 and ‐4) are epitopes of a unique globo‐series ganglioside isolated from human teratocarcinoma cells.

Reiji Kannagi, Nancy A. Cochran, Fumitsugu Ishigami et al. · The EMBO Journal · 1983 · 544 citations · Full text

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Binding of synthetic oligosaccharides to the hepatic Gal/GalNAc lectin. Dependence on fine structural features.

Y C Lee, R. Reid Townsend, Mark R. Hardy et al. · Journal of Biological Chemistry · 1983 · 495 citations · Full text

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A cell surface glycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos

François Hyafil, Dominique Morello, Charles Babinet et al. · Cell · 1980 · 413 citations

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