Angewandte Chemie International Edition · 2009 · 352 citations · 30 references
PharmacyCell BiologyPharmaceuticsDrug DeliveryIntracellular TransportNanoparticle Drug DeliveryDrug EncapsulationIntracellular Drug DeliveryNanomaterials For Drug DeliveryNanoparticle Delivery SystemsPolymeric Drug Delivery SystemsProtein DeliveryDrug Delivery NanocarriersDrug-loaded MicellesMicelle Drug DeliveryMicellesNanoparticle Intracellular TransportPolymeric MicellesPolymeric NanocarriersProtein Delivery Carriers
Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).
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