MGMT promoter methylation in plasma of glioma patients receiving temozolomide

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

Roger Stupp, Monika E. Hegi, Warren Mason et al. · The Lancet Oncology · 2009 · 7.8K citations

Medicine, Oncology, Radiation Oncology +17

<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma

Monika E. Hegi, Annie‐Claire Diserens, Thierry Gorlia et al. · New England Journal of Medicine · 2005 · 7.3K citations · Full text

Medicine, Molecular Biology, Oncology +17

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

Manel Esteller, Stanley R. Hamilton, P C Burger et al. · PubMed · 1999 · 1.3K citations

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Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial

Wolfgang Wick, Michael Platten, Christoph Meisner et al. · The Lancet Oncology · 2012 · 1.1K citations · Full text

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NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide

Wolfgang Wick, Christian Hartmann, Corinna Engel et al. · Journal of Clinical Oncology · 2009 · 807 citations

Medicine, Oncology, Radiation Oncology +16