Concepedia

Relative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin

Abu T.M. Serajuddin, Sunanda A. Ranadive, Eileen M. Mahoney

Journal of Pharmaceutical Sciences · 1991 · 202 citations · 16 references

DOI

Concepts

References

16

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

Yoshio Tsujita, Masao Kuroda, Yoko Shimada et al. · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1986 · 375 citations

, , +14

Reduction of Serum Cholesterol in Heterozygous Patients with Familial Hypercholesterolemia

Hiroshi Mabuchi, Takeshi Sakai, Yasuyuki Sakai et al. · New England Journal of Medicine · 1983 · 200 citations

, , +17

An investigation of the comparative liposolubilities of β-adrenoceptor blocking agents

P B Woods, Malcolm L. Robinson · Journal of Pharmacy and Pharmacology · 1981 · 175 citations

, , +5

Tissue selectivity of the cholesterol-lowering agents lovastatin, simvastatin and pravastatin in rats in vivo

John I. Germershausen, V. M. Hunt, Richard G. Bostedor et al. · Biochemical and Biophysical Research Communications · 1989 · 172 citations

, , +11

Comparative Pharmacokinetics and Pharmacodynamics of Pravastatin and Lovastatin

Henry Pan, Arthur R. DeVault, David Wang‐Iverson et al. · The Journal of Clinical Pharmacology · 1990 · 146 citations

, , +17