Human Stem Cell Derivatives Retain More Open Epigenomic Landscape When Derived from Pluripotent Cells than from Tissues

Abstract

Human Stem Cell Derivatives Retain More Open Epigenomic Landscape When Derived from Pluripotent Cells than from Tissues The ability of a stem cell both to self-renew and differentiate into desired phenotypes makes it a potentially inexhaustible cell source for tissue and functional restoration. Discerning the complex identities of human stem cell derivatives from various developmental stages and sources is essential for selection of an optimally lineage-committed human stem cell with sufficient plasticity along the fate restriction continuum to address a particular disease.