Concepedia

Dose-dependent teratogenicity of valproate in mono- and polytherapy

Torbjörn Tomson, Dina Battino, Erminio Bonizzoni, John Craig, Dick Lindhout, Emilio Perucca, Anne Sabers, Sanjeev V. Thomas, Frank Vajda

Neurology · 2015 · 157 citations · 18 references

DOIFull text

Open access

Abstract

The risk of MCMs associated with VPA exposure increases with increasing VPA dose, both in the presence and in the absence of one concomitant AED, and appears to be related primarily to the dose of VPA.

References

18

Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism

Jakob Christensen, Therese Koops Grønborg, Merete Juul Sørensen et al. · JAMA · 2013 · 1.3K citations · Full text

Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study

Kimford J. Meador, Gus A. Baker, N. Andrew Browning et al. · The Lancet Neurology · 2013 · 820 citations · Full text

, , +12

Cognitive Function at 3 Years of Age after Fetal Exposure to Antiepileptic Drugs

Kimford J. Meador, Gus A. Baker, N. Andrew Browning et al. · New England Journal of Medicine · 2009 · 812 citations · Full text

Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry

Torbjörn Tomson, Dina Battino, Erminio Bonizzoni et al. · The Lancet Neurology · 2011 · 738 citations

, , +5

Comparative safety of antiepileptic drugs during pregnancy

C. R. Smith, Aizong Shen, Robert Mittendorf et al. · Neurology · 2012 · 613 citations