Concepedia

Pharmacokinetics and <i>in vivo</i> potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys

Arzu Ulu, SE Appt, Christophe Morisseau, SH Hwang, Jones Pd, TE Rose, Hongzhi Dong, József Langó, Jun Yang, HJ Tsai,

British Journal of Pharmacology · 2012 · 68 citations · 27 references

DOIFull text

Open access

Abstract

Our data indicate that TPPU is suitable for investigating sEH biology and the role of epoxide-containing lipids in modulating inflammatory diseases in NHPs.

References

27

Anti-inflammatory Properties of Cytochrome P450 Epoxygenase-Derived Eicosanoids

Koichi Node, Yuqing Huo, Xiu-Lu Ruan et al. · Science · 1999 · 1.2K citations

Soluble epoxide hydrolase is a therapeutic target for acute inflammation

Kara Schmelzer, Lukáš Kubala, John W. Newman et al. · Proceedings of the National Academy of Sciences · 2005 · 439 citations · Full text

Quantitative Profiling Method for Oxylipin Metabolome by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry

Jun Yang, Kara Schmelzer, Katrin Georgi et al. · Analytical Chemistry · 2009 · 310 citations · Full text

Partitioning, Persistence, and Accumulation in Digested Sludge of the Topical Antiseptic Triclocarban during Wastewater Treatment

Jochen Heidler, Amir Sapkota, Rolf U. Halden · Environmental Science & Technology · 2006 · 274 citations

An Orally Active Epoxide Hydrolase Inhibitor Lowers Blood Pressure and Provides Renal Protection in Salt-Sensitive Hypertension

John D. Imig, Xueying Zhao, Constantine Z. Zaharis et al. · Hypertension · 2005 · 250 citations · Full text

, , +14