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From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: The discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis

Combinatorial ChemistryMedicinal ChemistryAcyclic ScaffoldsMedicineNatural SciencesMechanism Of ActionMolecular BiologyClick ChemistryPharmacologyEosinophil ChemotaxisDrug DiscoveryRigid Cyclic Templates