Increased Glucose Utilization in <i>Corynebacterium glutamicum</i> by Use of Maltose, and Its Application for the Improvement of <scp>l</scp> -Valine Productivity

Abstract

Corynebacterium glutamicum efficiently utilizes maltose as a substrate. We show here that the presence of maltose increases glucose utilization by raising the expression of ptsG, which encodes the glucose-specific EII permease of the phosphotransferase system. Consequently, the L-valine productivity of a pyruvate dehydrogenase complex-deficient C. glutamicum strain was improved by the presence of maltose.