Concepedia

Participation of Valine 171 in α-Helix 5 of <i>Bacillus thuringiensis</i> Cry1Ab δ-Endotoxin in Translocation of Toxin into <i>Lymantria dispar</i> Midgut Membranes

Óscar Álzate, Cristina Osorio, Álvaro M. Flórez, Donald H. Dean

Applied and Environmental Microbiology · 2010 · 17 citations · 11 references

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Abstract

The Cry1Ab δ-endotoxin V171C mutant protein exhibits a 25-fold increase in toxicity against Lymantria dispar, which correlates with a faster rate of partitioning into the midgut membrane and slightly decreased protein stability. This is an insect-specific mechanism; similar results were not observed in Manduca sexta, another Cry1Ab δ-endotoxin-susceptible insect.

References

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