Concepedia

Mitochondrial Crisis in Cerebrovascular Endothelial Cells Opens the Blood–Brain Barrier

Danielle N. Doll, Heng Hu, Jiahong Sun, Sara E. Lewis, James W. Simpkins, Xuefang Ren

Stroke · 2015 · 193 citations · 16 references

DOIFull text

Open access

Abstract

We concluded that mitochondria are key players in BBB permeability. These novel findings suggest a potential new therapeutic strategy for ischemic stroke by endothelial cell mitochondrial regulation.

References

16

Rotenone, Paraquat, and Parkinson’s Disease

Caroline M. Tanner, Freya Kamel, G. Webster Ross et al. · Environmental Health Perspectives · 2011 · 1.4K citations · Full text

Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells

Per Artursson · Journal of Pharmaceutical Sciences · 1990 · 824 citations · Full text

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Evidence of Reperfusion Injury, Exacerbated by Thrombolytic Therapy, in Human Focal Brain Ischemia Using a Novel Imaging Marker of Early Blood–Brain Barrier Disruption

Steven Warach, Lawrence L. Latour · Stroke · 2004 · 390 citations · Full text

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Systemic Inflammatory Stimulus Potentiates the Acute Phase and CXC Chemokine Responses to Experimental Stroke and Exacerbates Brain Damage via Interleukin-1- and Neutrophil-Dependent Mechanisms

Barry W. McColl, Nancy J. Rothwell, Stuart M. Allan · Journal of Neuroscience · 2007 · 333 citations · Full text

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Tight junction protein expression and barrier properties of immortalized mouse brain microvessel endothelial cells

Rachel C. Brown, Andrew P. Morris, Roger G. O’Neil · Brain Research · 2006 · 285 citations · Full text

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