PON1 M/L55 mutation protects high-risk patients against coronary artery disease

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

Randall K. Saiki, David H. Gelfand, Susanne Stoffel et al. · Science · 1988 · 17.2K citations

Life Sciences, Biotechnology, Molecular Biology +12

Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.

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Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

Diana M. Shih, Lingjie Gu, Yu-Rong Xia et al. · Nature · 1998 · 1.1K citations

Pharmacy, Biochemistry, Toxicology +9

The molecular basis of the human serum paraoxonase activity polymorphism

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Life Sciences, Biochemistry, Genetics +4

Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes.

M C Garin, Richard W. James, Philippe Dussoix et al. · Journal of Clinical Investigation · 1997 · 478 citations · Full text

Medicine, Genetics, Molecular Genetics +11