Visceral chemical nociception in mice lacking μ-opioid receptors: effects of morphine, SNC80 and U-50,488

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Medicine, Neuroscience, Pharmacology +17

THE ABDOMINAL CONSTRICTION RESPONSE AND ITS SUPPRESSION BY ANALGESIC DRUGS IN THE MOUSE

H. O. J. COLLIER, L. C. Dinneen, Christine A. Johnson et al. · British Journal of Pharmacology and Chemotherapy · 1968 · 1.2K citations · Full text

Medicine, Anatomy, Physiology +7

Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia

Ichiro Sora, Nobuyuki Takahashi, Masahiko Funada et al. · Proceedings of the National Academy of Sciences · 1997 · 528 citations

Nursing, Pharmacology, Neuropharmacology +16

In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat.

Claudia Schmauss, Tony L. Yaksh · Journal of Pharmacology and Experimental Therapeutics · 1984 · 417 citations

Medicine, Pharmacology, Behavioral Pharmacology +16

Activity of the δ-Opioid Receptor Is Partially Reduced, Whereas Activity of the κ-Receptor Is Maintained in Mice Lacking the μ-Receptor

Hans W. D. Matthes, Claire Smadja, Olga Valverde et al. · Journal of Neuroscience · 1998 · 199 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17