Concepedia

Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells

Hidetaka Miyagi, Soshi Kanemoto, Atsushi Saito, Rie Asada, Hideo Iwamoto, Soutarou Izumi, Miori Kido, Fumi Gomi, Kohji Nishida, Yoshiaki Kiuchi,

PLoS ONE · 2013 · 26 citations · 35 references

DOIFull text

Open access

Abstract

We have demonstrated a novel regulatory mechanism for VEGFA transcription by OASIS in human retinal pigment epithelial cells. Chemical compounds that regulate the binding of OASIS to the promoter region of the VEGFA gene may have potential as therapeutic agents for ocular diseases with neovascularization.

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