Concepedia

Some lessons about models from Michaelis and Menten

Jeremy Gunawardena

Molecular Biology of the Cell · 2012 · 46 citations · 7 references

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Abstract

Michaelis and Menten's classic 1913 paper on enzyme kinetics is used to draw some lessons about the relationship between mathematical models and biological reality.

References

7

The Original Michaelis Constant: Translation of the 1913 Michaelis–Menten Paper

Kenneth A. Johnson, Roger S. Goody · Biochemistry · 2011 · 1.4K citations

, , +14

Fundamentals of enzyme kinetics

Choice Reviews Online · 1996 · 664 citations

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Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

William W. Chen, Birgit Schoeberl, Paul Jasper et al. · Molecular Systems Biology · 2009 · 405 citations · Full text

, , +16

THE KINETICS OF THE ENZYME-SUBSTRATE COMPOUND OF PEROXIDASE

Britton Chance · Journal of Biological Chemistry · 1943 · 334 citations · Full text

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Unlimited multistability in multisite phosphorylation systems

Matthew Thomson, Jeremy Gunawardena · Nature · 2009 · 258 citations · Full text

, , +8