Convection Enhanced Delivery: A Comparison of infusion characteristics in ex vivo and in vivo non-human primate brain tissue

Abstract

We detected higher ratios in the in vivo subjects than in ex vivo. This difference could be explained by the extra cellular space volume fraction. Studies evaluating backflow and morphology use in vivo tissue as a medium are recommended. Further investigation is warranted to evaluate the role blood pressure and heart rate may play in human CED clinical trials.

References

Page 1

	Year	Citations
Convection-enhanced delivery of macromolecules in the brain. R. Hunt Bobo, Douglas W. Laske, Aytaç Akbaşak, Proceedings of the National Academy of Sciences Interstitial InfusionPharmaceutical ScienceNeurophysiologyMedicineInfusion Solution	1994	1.4K
Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease Jeffrey H. Kordower, Marina E. Emborg, Jocelyne Bloch, Science	2000	1.2K
High-flow microinfusion: tissue penetration and pharmacodynamics Paul F. Morrison, Douglas W. Laske, Hunt Bobo, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology EngineeringReperfusion InjuryMedicineHigh-flow MicroinfusionRapid Degradation Rates	1994	318
The “Perivascular Pump” Driven by Arterial Pulsation Is a Powerful Mechanism for the Distribution of Therapeutic Molecules within the Brain Piotr Hadaczek, Yoji Yamashita, Hanna Mirek, Molecular Therapy Viral PathogenesisBiomedical EngineeringInfused MacromoleculesCerebral Vascular RegulationBlood Flow	2006	300
Focal delivery during direct infusion to brain: role of flow rate, catheter diameter, and tissue mechanics Paul F. Morrison, Michael Y. Chen, Richard S. Chadwick, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology EngineeringFluid MechanicsBiomedical EngineeringBlood FlowCerebral Vascular Regulation	1999	205
Lentiviral Gene Transfer to the Nonhuman Primate Brain Jeffrey H. Kordower, Jocelyne Bloch, Yaping Chu, Experimental Neurology XenotransplantationLentiviral Gene TransferNeuroscienceGene VectorMedicine	1999	197
Lentiviral Vectors as a Gene Delivery System in the Mouse Midbrain: Cellular and Behavioral Improvements in a 6-OHDA Model of Parkinson's Disease Using GDNF Jean‐Charles Bensadoun, Nicole Déglon, Jack Tseng, Experimental Neurology Gene Delivery SystemMouse MidbrainLentiviral VectorsAntiviral ResponseNeuroscience	2000	185
Neuroprotective Effect of a CNTF-Expressing Lentiviral Vector in the Quinolinic Acid Rat Model of Huntington's Disease Luís Pereira de Almeida, Diana Zala, Patrick Aebischer, Neurobiology of Disease	2001	157
Interventional MRI-guided Putaminal Delivery of AAV2-GDNF for a Planned Clinical Trial in Parkinson's Disease R. Mark Richardson, Adrian P. Kells, Kathryn H. Rosenbluth, Molecular Therapy	2011	143
Postoperative Curving and Upward Displacement of Deep Brain Stimulation Electrodes Caused by Brain Shift Pepijn van den Munckhof, Maria Fiorella Contarino, Lo J. Bour, Neurosurgery	2010	111

Page 1