Concepedia

Convection Enhanced Delivery: A Comparison of infusion characteristics in ex vivo and in vivo non-human primate brain tissue

Gurwattan S. Miranpuri, Angelica Hinchman, Anyi Wang, Dominic T. Schomberg, Ken Kubota, Martin Brady, Raghu Raghavan, Kevin Bruner, Ethan K. Brodsky, Walter F. Block,

Annals of Neurosciences · 2013 · 13 citations · 25 references

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Abstract

We detected higher ratios in the in vivo subjects than in ex vivo. This difference could be explained by the extra cellular space volume fraction. Studies evaluating backflow and morphology use in vivo tissue as a medium are recommended. Further investigation is warranted to evaluate the role blood pressure and heart rate may play in human CED clinical trials.

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