Concepedia

Rapamycin Analogs with Differential Binding Specificity Permit Orthogonal Control of Protein Activity

J. Henri Bayle, Joshua S. Grimley, Kryn Stankunas, Jason E. Gestwicki, Thomas J. Wandless, Gerald R. Crabtree

Chemistry & Biology · 2006 · 209 citations · 24 references

DOI

Concepts

References

24

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Jun S. Liu, Jesse D. Farmer, Willam S. Lane et al. · Cell · 1991 · 4.1K citations

, , +8

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Eric J. Brown, Mark W. Albers, Tae Bum Shin et al. · Nature · 1994 · 2.1K citations

, , +11

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

David M. Sabatini, Hediye Erdjument‐Bromage, Mary Lui et al. · Cell · 1994 · 1.5K citations

, , +8

Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP

Jung‐Won Choi, Jie Chen, Stuart L. Schreiber et al. · Science · 1996 · 930 citations

, , +17

Controlling Signal Transduction with Synthetic Ligands

David M. Spencer, Thomas J. Wandless, Stuart L. Schreiber et al. · Science · 1993 · 854 citations

, , +17